NB BIOTINA

As a potent and highly selective Dipeptidyl Peptidase-4 (DPP-4) inhibitor, NB BIOTINA is meticulously formulated to enhance your body’s natural ability to regulate blood glucose levels. It specifically targets the incretin system, promoting insulin release only when blood sugar is elevated and reducing excessive glucose production by the liver. When combined with a healthy diet and regular exercise, NB BIOTINA provides reliable, 24-hour glycemic control, helping to prevent the long-term complications associated with Type 2 Diabetes with a favorable safety profile and remarkable tolerability.

Why Choose NB BIOTINA for Your Type 2 Diabetes Management?

NB BIOTINA offers a sophisticated, comprehensive, and well-tolerated approach to glucose control:

• Glucose-Dependent Insulin Secretion: Teneligliptin enhances the release of insulin from the pancreatic beta cells in a glucose-dependent manner. This means it primarily stimulates insulin production when blood sugar levels are high, minimizing the risk of hypoglycemia (dangerously low blood sugar) when used as monotherapy.
• Reduces Hepatic Glucose Production: It also effectively suppresses excessive glucagon secretion, which in turn reduces the amount of glucose produced by your liver, a key contributor to elevated fasting and post-meal blood sugar.
• Effective HbA1c Reduction: NB BIOTINA provides consistent and clinically significant reductions in HbA1c (Glycated Hemoglobin), a crucial indicator of long-term blood sugar control, contributing to better overall diabetes management and improved outcomes.
• 24-Hour Efficacy: Teneligliptin’s unique structure allows for potent and long-lasting DPP-4 inhibition, providing sustained glycemic control throughout the entire 24-hour period with convenient once-daily dosing.
• Weight Neutrality: Teneligliptin is generally considered weight-neutral, meaning it typically does not cause weight gain, which is a significant advantage for many individuals with Type 2 Diabetes who are often managing weight concerns.
• Renal Safety & Broad Applicability: NB BIOTINA (Teneligliptin) exhibits dual excretion pathways (renal and hepatic), often making it a suitable option for patients with mild to moderate renal impairment without requiring dose adjustments, offering flexibility in patient management (always consult your doctor for specific guidance based on your kidney function).
• Well-Tolerated Profile: NB BIOTINA is generally well-tolerated by patients, with a low incidence of common side effects, making it a preferred choice for long-term adherence.
• Prevents Diabetes Complications: By consistently maintaining blood sugar levels within a healthy range, NB BIOTINA plays a crucial role in preventing or delaying the onset and progression of severe diabetes-related microvascular (eyes, kidneys, nerves) and macrovascular (heart, brain) complications.

Key Benefits of NB BIOTINA at a Glance:

• Precise & Sustained Glucose Control: Lowers blood sugar effectively, primarily when elevated, for 24 hours.
• Enhances Natural Insulin: Boosts the body’s own insulin response in a glucose-dependent manner.
• Reduces Liver Glucose Output: Targets a key source of high blood sugar.
• Weight-Neutral: Typically does not cause unwanted weight gain.
• Once-Daily Dose: Convenient for consistent, daily management.
• Favorable Renal Profile: Often suitable for patients with varying degrees of kidney function.
• Prevents Complications: Helps minimize risks to vital organs.

Important Usage Instructions for NB BIOTINA:

Always take NB BIOTINA exactly as prescribed by your doctor. Consistent adherence is vital for maintaining effective blood sugar control.

• Take one tablet (20mg) once daily, at approximately the same time each day, with or without food, or as directed by your physician.
• Swallow the tablet whole with water; do not crush, chew, or break it.
• Do not stop taking this medication suddenly without consulting your doctor, even if your blood sugar seems controlled.
• Regular monitoring of your blood sugar levels and HbA1c by your doctor is essential during treatment.
• Be aware of potential serious, though rare, side effects such as pancreatitis (severe, persistent abdominal pain radiating to the back, with or without vomiting) or severe allergic reactions (rash, hives, swelling of face/lips/tongue/throat, difficulty breathing/swallowing); seek immediate medical attention if these occur.
• Inform your doctor about any pre-existing medical conditions, especially a history of pancreatitis or kidney disease.

Understanding How NB BIOTINA Works to Control Blood Sugar:

Teneligliptin, the active ingredient in NB BIOTINA, belongs to the class of medications known as Dipeptidyl Peptidase-4 (DPP-4) inhibitors. Its mechanism of action is designed to enhance the body’s natural “incretin” system for glucose regulation:

• Incretin Hormones: After a meal, the intestines naturally release incretin hormones, primarily glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones are crucial for blood sugar control as they:
  • Stimulate insulin release from the pancreatic beta cells in a glucose-dependent manner (meaning insulin is released more when blood sugar is high).
  • Suppress glucagon secretion from the pancreatic alpha cells (glucagon raises blood sugar).
  • Slow down gastric emptying (which helps reduce post-meal glucose spikes).
• DPP-4 Enzyme: Under normal physiological conditions, incretin hormones are rapidly broken down and inactivated by the enzyme DPP-4 in the bloodstream.
• Inhibition by Teneligliptin: NB BIOTINA (Teneligliptin) works by selectively inhibiting the DPP-4 enzyme. By blocking DPP-4, Teneligliptin allows the body’s own incretin hormones (GLP-1 and GIP) to remain active in the circulation for a longer duration and at higher concentrations.
• Enhanced Glucose Control: The prolonged action of incretins leads to:
  • Increased and sustained insulin secretion from the pancreas, but only when blood sugar levels are elevated, thereby reducing the risk of hypoglycemia.
  • Decreased glucagon secretion, which in turn reduces glucose production by the liver.

Teneligliptin’s specific “J-shaped” binding to the active site of the DPP-4 enzyme provides robust and sustained inhibition, leading to continuous glycemic control throughout the day and night. This precise mechanism allows NB BIOTINA to effectively lower both fasting and post-meal blood sugar levels, contributing to improved glycemic control with a low risk of hypoglycemia.